Hi Andy - I had a Yaesu VX-7R - I had a tough time getting the clock set
I wouldn't worry so much about how to organize things just yet. It will really depend on how you use the radio. For my handhelds, I tend to program the local repeater I'm most likely to use in the call (home) channel and the first standard memory channel, then the rest tend to fall into place as I use them. Every so often I'd change things around depending on what repeaters I was using.
73 de Joseph Durnal NE3R
Joseph Durnal - [callsign]NE3R[/callsign] ex N3PAQ