Can I run a Hermes Lite 2 from a Mac Mini? Sure, I can. But that's because I'm writing my own SDR software, mostly from scratch. Currently I've just got basic Rx/Tx functionality working, sufficient for 1 CW QSO from the Mac keyboard, 1 SSB QSO using my AirPods, and a lot of SWL and FT8 skimming. Same software runs on iPads as well. Currently in beta-test. I also use a Hermes Lite 2 with SDR code on a Raspberry Pi 4 for WSPR beacon transmissions, mostly on 20M. But you're probably interested in software with a lot more features that's been around a lot longer.