Independent Sideband has great possibliities for amateur radio. Back in the 1970s there was some flirtation with the technique (see May, 1977 QST) but it never really caught on. The main application was with SSTV...you could send your photos on upper sideband and audio on lower sideband. It was actually quite a lot of work to set this up...but with new DSP techniques it should be a snap.
But I see something even cooler about ISB. With a very well aligned system, you could run FULL DUPLEX SSB on HF. (Maritime radio has used full duplex H.F. for years, but with widely separated channels. With a good ISB system, ou could talk and listen at the same time on the same "carrier" frequency...one direction on usb and the other on lsb. With a high isolation hybrid or circulator, you could even use the same antenna. I think this is something worth experimenting with.