For all you vintage OS fans... Today I figured out a way to make a MS DOS 6.22 Bootable USB stick. It was kind of tricky. I needed to do this to get an old Needham's Electronics EMP-10 EPROM programmer running. I couldn't do it virtually (at least not in VirtualBox) because the EPROM programmer needed a native connection to the parallel port. This is how I did it: REQUIREMENTS USB Stick - I used a 128MB stick MS DOS 6.22 Floppy Images - I found them here Oracle VirtualBox BIOS that supports booting from USB HDD INSTRUCTIONS Run DISKPART. Select and clean the USB Stick. Here's the tricky part. Create a link in VirtualBox to the physical USB stick. This website shows you how to do it. When you open your command windows, run cmd as an administrator or it won't work. Run VirtualBox as an administrator. Create a virtual machine and add the physical USB stick to the IDE controller. Add the first MS DOS 6.22 setup disk image to the floppy controller. Boot the virtual machine and install DOS. Exit VirtualBox and reboot your computer. Before your computer boots to your hard drive, press the key to enter the boot menu. On my computer, you hit F12 for the boot menu. My USB stick shows up in the list of hard drives. Enjoy flashing back to 1985! My instructions were brief because I'm not sure if anyone cares about this. I thought it was pretty cool myself. To think I ran this software on an IBM XT with a Intel 8088 and a 20MB Seagate ST-225! If anyone wants a detailed explanation of any of the steps or has any questions, please ask.